The objective of the study was to analyze the impact of yoga therapy in the Respiratory function and oxidative stress in the middle age group. The study is carried out in the department of Human consciousness and Yogic Sciences, Mangalore University, Dakshina Kannada District, Kranataka. 40 subjects with age group 45-60 years were selected for this study. The subjects suffering from breathlessness in the middle age group are included in the present study. The yoga therapy sessions were conducted regularly one hour except every Sundays. Case history was taken in the beginning of the study. Proper sequence of asanas, pranayamas and relaxation techniques was maintained during yogic practice session. The subjects were advised to systematize their good habits and were asked to take light easily digestible food. Subjects were asked to avoid excess curds, fried items and food containing excess of oils and fats. During yogic practice session individual concentration given to the subjects and mainly concentration given to the synchronization of breath along with the body movement. Parameters considered are: MVV (Maximum Voluntary Ventilation), PEFR (Peak Expiratory Flow Rate), Malondialdehyde (MDA). When results were compared with control group, experimental group shows significant changes, which clearly shows the effect of yogic practices.