The study aims are to assess the knowledge of nursing students regarding home care management of colostomy and to identify the relationship between the knowledge level and socio demographic variables of nursing students. The quantitative research approach and descriptive design was adopted for the study. The study was conducted in Narayana College of nursing in Nellore. 30 nursing students were selected by using Non Probability Convenience Sampling Technique. Structured Questionnaire method was used for collecting the information from samples. Data analysis done by using descriptive and inferential statistics. The results revealed that 5(16.6%) Nursing students had adequate knowledge, 18(60%) had moderately adequate knowledge and 7(23.3%) Nursing students had inadequate knowledge regarding preservation of food. The study concluded that majority of nursing students has moderately adequate knowledge regarding home care management of colostomy. Hence there is a need to educate regarding the colostomy care thereby can deliver the effective health education to patients with home care management of colostomy.