The present study was conducted to find out the effect of extraversion and neuroticism on teacher effectiveness. To conduct the study 320 female teachers working in government schools operational in and around Raipur were selected as sample. Stratified random sampling was employed to meet the demand of 2x2 factorial design. Hindi version of Eysenck Personality Questionnaire (EPQ) prepared by Jitendra Mohan (1985) was used to assess extraversion and neuroticism while teacher effectiveness scale prepared by Kumar and Mutha (1983) were used to assess effectiveness of teacher. Results showed significant main effect of extraversion and neuroticism on teacher effectiveness but interaction effect of these two variables was not observed on teacher effectiveness. It was concluded that extraversion and neuroticism alone and not in interaction with each other influence teacher effectiveness in a group of female teachers.