Stress and hardship in children are caused by various vulnerability factors like abuse, neglect, chronic diseases, exposure to violence, death of a parent and mental illness of caregivers can affect adversely a growing child. The physiological changes, in turn, raise the risk of cognitive and developmental delays, physical health problems, behavioral and mental health problems and increase child’s inability to cope up with situation. Building resilience in children, who are at high risk, is very essential for their integrated growth and wellbeing. Adopting appropriate social work strategies can enhance the resilience of children who are at high risk. A few case studies presented in this research paper affirm that resilience of children at high risk can be enhanced by applying different social work methods and approaches. The study suggests further research in this field.