Background: Maternal Mortality Rate (MMR) in Indonesia is still quite high and ranks second in Southeast Asia, this shows that there is an increase in maternal health problems. One of the highest causes of maternal and fetal mortality and morbidity is the result of hypertension. Besides hypertension is caused by oxidative stress which triggers the emergence of free radicals in the body of pregnant women. Compounds that can prevent or inhibit damage caused by free radicals are antioxidants. Fruits contain a lot of antioxidants, one of which is mangosteen peel, because mangosteen peel has a very high antioxidant content that exceeds vitamin E and vitamin C which has been known as the highest antioxidant. Objective: Knowing the use of mangosteen peel extract (Garcinia Mangostana Linn) as an alternative to controlling endothelial cell degeneration in pregnant mice with hypertension. Method: The type of research used is Tru-Experimental with Posttest only control group design. This study arranged five groups: three treatment groups were given mangosteen peel extract at doses of 100 mg, 200 mg and 300 mg, while the two control groups were mice that were normal pregnant without treatment and pregnant mice with hypertension without treatment. Technique Probability sampling with method simple random sampling is used to obtain 25 mice (Musmuculus) were divided into five groups of 5 mice each. Results: The test results One Way Anova and Post hoc Multiple Comparisons showed a p value = 0.000 which means that there was an effect of giving mangosteen peel extract (Garcinia Mangostana L) to Malondialdehyde (MDA) levels in pregnant mice with hypertension. Conclusion: Mangosteen peel extract (Garcinia Mangostana L) at doses of 100 and 200 mg/Kg weight /day given for 10 days can affect oxidative stress (MDA) in mice (Mus Musculus) pregnant with hypertension model.