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VOL. 6, ISSUE 4 (2021)
Acute toxicity study in rats based on physiological examination using aqueous extract of Eugenia uniflora (L.) leaves
Authors
Geedhu Daniel
Abstract
The present study aims to investigate the acute toxicity study in aqueous leaf extract of Eugenia uniflora leaves in rats by examination of physiological parameters. Male Wistar albino rats weighing 170-200g were used for the study. The animals were maintained in a ventilated room with temperature 23± 2oC, humidity 60-70% and 12h light/dark cycle. Animals were fed with standard pellet and water ad libitum. All the studies were conducted in accordance with committee for the purpose of control and supervision of experiments on animals (CPSEA) norms and the National Institute of Health Guidelines “Guide for the care and use of laboratory animals”. The animals were observed daily for physiological and behavioral changes. Body weight were taken daily before the administration of extract for 28 days. After the end of experimental regimen the animals were sacrificed and blood was collected by cervical decapitation under mild chloroform anaesthesia. From the physiological parameters examined the extract showed non toxic nature even at the highest dosage. However, more studies should be conducted for further understanding.
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Pages:22-24
How to cite this article:
Geedhu Daniel "Acute toxicity study in rats based on physiological examination using aqueous extract of <em>Eugenia uniflora</em> (L.) leaves ". International Journal of Multidisciplinary Education and Research, Vol 6, Issue 4, 2021, Pages 22-24
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