The current study has been undertaken to assess knowledge score regarding lifestyle modification for prevention of myocardial infraction among peoples in Indore. The research design used for study was descriptive in nature. The tool for study was self-structured questionnaire which consists of 3 parts- PART- I consisted questions related to Socio-demographic data, PART-II Checklist for practice and PART-II consisted of self -structured knowledge questionnaire to assess knowledge score regarding lifestyle modification for prevention of myocardial infraction among peoples. The data was analyzed by using descriptive & inferential statistical methods. The self-structured knowledge questionnaires consisted of 20 questions. For maximum 1 mark was given, the score was further graded as poor (0-5), average (6-10), good (11-15) and excellent (16-20) In assessment stage, 11 (18.3%) peoples were having poor knowledge score while 49 (81.7%) were having average knowledge score, each 0 (0.0%) peoples were having good and excellent knowledge score.